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Image Search Results
Journal: bioRxiv
Article Title: A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
doi: 10.1101/2023.11.08.566163
Figure Lengend Snippet: (A) Schematic representation of the human IL23A transgene . (B) human IL23A mRNA detected by PCR and (C) human IL23A protein detected by immunohistochemistry in the skin, cervical lymph nodes, spleen, lung and kidney of TghIL23A mice. Scale bar 200μm and 100μm.
Article Snippet: Tissue paraffin sections were stained with H&E for histopathological evaluation or with biotinylated anti-mouse-IgG (Vector; BA-9200) for the detection of immune complex deposits and
Techniques: Immunohistochemistry
Journal: bioRxiv
Article Title: A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
doi: 10.1101/2023.11.08.566163
Figure Lengend Snippet: Reduced skin (upper panel) and ear (lower panel) clinical (A) and histopathological signs (B), as well as reduced LN/BW and Spleen/BW ratios (C) , urine protein levels (D) IgG circulating levels (E) and glomerular IgG deposits (F) following a 10-week-long treatment of TghIL23A mice with anti-human IL23A (Guselkumab:GUS). Scale bar 20μm. Data are presented as mean ± SEM; * P < 0.04; ** P < 0.0092; *** P = 0.0002; **** P < 0.0001.
Article Snippet: Tissue paraffin sections were stained with H&E for histopathological evaluation or with biotinylated anti-mouse-IgG (Vector; BA-9200) for the detection of immune complex deposits and
Techniques: